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<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd">
<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="orthopaedics" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">144</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2023.30104</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Orthopaedics</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Inflammation Process, Outcome and Prevention of Post-Traumatic Osteoarthritis&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Sunbol</surname>
            <given-names>Khalid</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>aldahan</surname>
            <given-names>Bashier Al</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Mubarak</surname>
            <given-names>Hussain Al</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Bozaid</surname>
            <given-names>Zainab</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alqahtani</surname>
            <given-names>Ibrahem</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Basarwan</surname>
            <given-names>Abdullah</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alabbadi</surname>
            <given-names>Albaraa</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alghamdi</surname>
            <given-names>Turki</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Akkasi</surname>
            <given-names>Hatim</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Redha</surname>
            <given-names>Husain</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Almassaud</surname>
            <given-names>Hisham</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>6</day>
        <month>01</month>
        <year>2023</year>
      </pub-date>
      <volume>3</volume>
      <issue>1</issue>
      <fpage>19</fpage>
      <lpage>24</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Osteoarthritis is a prominent cause of disability with rising prevalence and incidence. An essential risk factor for posttraumatic osteoarthritis, joint injury history has a substantial role in the rapidly rising prevalence of osteoarthritis in the general population. A prolonged trauma associated with recurring instability leads to the development of posttraumatic oesteoarthritis, which commonly affects the knee and ankle joints. Due to the high number of knee and ankle injuries that occur each year and the strong association between joint damage and the development of osteoarthritis, posttraumatic osteoarthritis represents a significant public health burden. The onset of the chronic disease seems to be significantly influenced by the activation of inflammatory pathways during the posttraumatic osteoarthritis acute phase. Immediately following joint trauma, a number of inflammatory mediators are secreted in synovial fluid. These inflammatory mediators are the predictors of the disease. The purpose of this research is to review the available information about inflammation process, outcome and prevention of post-traumatic osteoarthritis. The continued activation of innate inflammatory pathways may contribute to the maintenance of inflammation and the development of posttraumatic osteoarthritis in the injured joint. Various studies reported more complications observed in posttraumatic osteoarthritis patients as compared to others after knee arthroplasties. Prevention of posttraumatic osteoarthritis shall be targeted before the initiation of clinical onset of posttraumatic osteoarthritis. Anti-inflammatory drugs with sustained delivery can be more beneficial in prevention of cartilage degeneration although further research is needed to study and develop preventive strategies for posttraumatic osteoarthritis.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>osteoarthritis</kwd>
        <kwd> posttraumatic</kwd>
        <kwd> prevent</kwd>
        <kwd> inflammation</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>