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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="family-medicine" lang="en">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher">JOHS</journal-id>
      <journal-id journal-id-type="nlm-ta">Journ of Health Scien</journal-id>
      <journal-title-group>
        <journal-title>Journal of HealthCare Sciences</journal-title>
        <abbrev-journal-title abbrev-type="pubmed">Journ of Health Scien</abbrev-journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2231-2196</issn>
      <issn pub-type="opub">0975-5241</issn>
      <publisher>
        <publisher-name>Radiance Research Academy</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">402</article-id>
      <article-id pub-id-type="doi">http://dx.doi.org/10.52533/JOHS.2025.50602</article-id>
      <article-id pub-id-type="doi-url"/>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Family Medicine</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Dyslipidemia in Diabetes: Understanding the Role of Insulin in Lipid Metabolism&#13;
</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Alsubhi</surname>
            <given-names>Mohammed Ibrahim</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Sherbini</surname>
            <given-names>Rahaf Talal</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alkhalifah</surname>
            <given-names>Ali Hussain</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alnajjar</surname>
            <given-names>Wed Ziyad</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alqarni</surname>
            <given-names>Hussain Ali</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alsufyani</surname>
            <given-names>Shahad Ali</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alharbi</surname>
            <given-names>Rahaf Khalid</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Alfaqih</surname>
            <given-names>Yousef Hassan</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Khuraybah</surname>
            <given-names>Sarah Mohammed</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date pub-type="ppub">
        <day>13</day>
        <month>06</month>
        <year>2025</year>
      </pub-date>
      <volume>5</volume>
      <issue>6</issue>
      <fpage>189</fpage>
      <lpage>195</lpage>
      <permissions>
        <copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement>
        <copyright-year>2009</copyright-year>
        <license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/">
          <license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Diabetes Mellitus (DM) is one of the most prevalent chronic conditions worldwide, with an estimated incidence of 592 million globally by 2035. DM can lead to various serious complications, including diabetic nephropathy, peripheral arterial disease, central and peripheral neuropathy, coronary artery disease, diabetic retinopathy, stroke, and cardiomyopathy. One of the most important macrovascular complications of DM is diabetic dyslipidemia. It is more prevalent in type 2 diabetes (T2D) than in type 1 diabetes (T1D), as T2D is associated with insulin resistance. In normal states, lipid metabolism is mainly regulated by insulin; thus, IR linked to T2D leads to multiple lipid metabolism aberrations. Under normal conditions, insulin promotes hepatic lipid storage and synthesis while suppressing fatty acid oxidation. It also induces de novo lipogenesis through stimulating the expression of lipogenic genes. In healthy conditions, insulin suppresses very-low-density lipoprotein (VLDL) production, preventing excessive lipid export into circulation. However, insulin resistance is associated with increased VLDL secretion, contributing to hypertriglyceridemia?. Although a correlation between hyperinsulinemia and hypertriglyceridemia was observed, the exact mechanisms of how insulin affects lipid metabolism, especially in diabetes dyslipidemia, are still not fully understood. The aim of this review is to discuss dyslipidemia in diabetes, its pathophysiology and treatment, as well as the role of insulin in lipid metabolism.&#13;
</p>
      </abstract>
      <kwd-group>
        <kwd>Dyslipidemia</kwd>
        <kwd> Insulin</kwd>
        <kwd> Insulin Resistance</kwd>
        <kwd> Lipid Metabolism</kwd>
        <kwd> Diabetes Mellitus</kwd>
        <kwd> Diabetic Dyslipidemia</kwd>
      </kwd-group>
    </article-meta>
  </front>
</article>